
The mysterious work of Dr. Sergio Canavero is the stuff of grade-B horror movies. He claims heβs successfully attached a living mouse head to a rat, severed the spines of mice, and perhaps most impressively: reattached them.
His quest for the scientific holy grail lead to papers detailing two-headed creatures, a transplanted dogβs head, and bold claims about the first human head-transplant β which he plans to undertake later this year. Beyond that heβs said that he will be able to resuscitate a frozen brain within a few years.
Dr. Canavero has a reputation for making medical claims that sound a bit far-fetched, and thatβs not for nothing. He doesnβt just want to solve the problem with spinal reattachment, nor are his sights set on simply performing the worldβs first human head transplant. Canavero insists that his ultimate goal is that most quixotic of pursuits: immortality.
Dr. Frankenstein for a modern era
The medical community has its concerns. For one, Canavero would have to attach millions of tiny nerves, a problem he says heβs solved by using a fusogen (sealant) comprised of polyethylene glycol (PEG). This gel substance works like a glue. Itβs nothing new: PEG is used in a variety of biological and commercial applications, such as laxatives and skin cream.
In his research paper, Canavero explains:
β¦a sufficient number of axonal proximal stumps get fused with the distal counterparts in such a way to ensure appropriate electrophysio-logical conduction, likely the result of tight axonal packing. This number is likely low (10β15%), and yet enough for recovery, reflecting the potential for substantial plasticity in the injured
This is an observation by Dr. Canavero, not an explanation. His work, often, reads like that. He reports results without overcoming the obstacles we have in understanding how he arrived there. Other scientists are less kind, calling him an outright provocateur of the impossible. Heβs been called crazy by the media.
Whereβs the proof?
Dr. Canavero continues to publish papers with tantalizing claims, while offering little in the way of explanation. Is he a fraud? The relative ease with which we can dismiss him certainly makes it seem that way.
Why isnβt he the most famous doctor in the world? Why arenβt neurosurgeons around the globe leaping on the bandwagon?
The answer lies in the fact heβs beholden to no institute or research group. An Italian scientist is performing work thatβs, usually, banned in Europe and the US β without the assistance of a laboratory headquarters. Heβs bounced around from Russia to China in search of government support and a lot of that is difficult to track.
His problems run deeper than procedure, or financing. There are legitimate ethical concerns.
When Doctor Canavero claims heβs severed the spines of 18 mice and only reattached those of 9 some of us cringe. Upon discovering that heβs performed the procedure on a dog, there are plenty β who were okay with him butchering rats β that now draw the line when itβs manβs best friend heβs experimenting on.
Imagine then, what happens when he tries the operation with people. The head transplant is going to require three humans to put their lives on the line. And thereβs no road back from losing patients in an experiment that, ethically at-least, the world just isnβt ready for.

The surgery requires funding, the results must be self-evident, and science requires peer-review before anyone in the United States or Europe would take him seriously. Trying to make the world believe you can do things no other surgeon would even attempt seems like a pretty big bluff, if heβs lying.
Everything about these alleged medical feats seems shrouded in mystique; itβs all very cloak-and-dagger. The research papers read like the manifestations of a Doctor with a charmed life; everything works perfectly according to hypothesis.
Itβs 2017 and Dr. Canavero claims heβs performing mind-blowing procedures; it boggles the mind that he doesnβt have hundreds of hours of video evidence to support his claims. Instead thereβs been vague research papers and larger-than-life claims to go on. What heβs really doing β and who is helping him β remain a mystery.
Dr. Canavero should then be content to toil away in his evil hide-out. He should remain ambiguous in his explanations. The better for the rest of us to ignore his insanity. Unless heβs right.
What happens if heβs right?
The other result, a successful human head-transplant, seems improbable; yet it must be considered. The ramifications of being able to reconnect spinal tissue go far beyond solving paralysis: theyβre the first step to living forever.
But there are numerous problems with this procedure. It presents a tapestry of difficulty that the greatest of medical minds β so far β havenβt come close to overcoming. Probably because his work is the stuff of fantasy made with whimsical predictions, but perhaps our modern Dr. Frankenstein has unlocked the secrets and weβll all be believers soon.
The scientific community seems to be largely ignoring Dr. Canavero, and when they arenβt, they certainly donβt have many kind things to say. Heβs a pseudo-scientist, some have said β others have pointed out that what heβs talking about simply canβt be done yet.
The picture being painted, of a mad scientist, doesnβt take many brush strokes. His seemingly endless amount of confidence in his work piques the interest, but at the same time it puts off rational conversation.
In the improbable event that he were to pull off his claims; the world would be stunned. Weβd have to be; this is as big as time-travel, or proof of intelligent life beyond our planet. Science would have to take him seriously if he somehow raised the funding, found the right place, and pulled off the first human head-transplant.
It would be hailed miraculous
The world would pay attention to his thoughts on frozen brains, and other fancies of science fiction. The quack would become the authority! Heβd be a leading voice in the medical and science communities.
Whether heβs playing God or not seems to be a question we can only answer if he succeeds. Failure, though likely, would be far less interesting. The mystery surrounding Dr. Canavero will surely fade once he becomes another obscure dreamer whose rhetoric far exceeded his reach.
Unless he succeeds, in which case we wonβt be able to say βwe called itβ βbut at least we considered it.
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