Grandparents are the parents of a person's own parent, whether that be a father or a mother. Every sexually-reproducing creature who is not a genetic chimera has a maximum of four genetic grandparents, eight genetic great-grandparents, sixteen genetic great-great-grandparents, etc. Rarely, such as in the case of sibling or half-sibling incest, these numbers are lower.
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There's something charming whenever you hear stories about gamers who don't fit the preconceived notion of what a "gamer" ...